Hydrazine hydrate (1:1) → 3-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile

HRID 503170ノート

反応式

HRID 503170 の反応式
F[C:2]1[C:9]([O:10][CH3:11])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:12](=O)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1.O.[NH2:22][NH2:23]>C(O)C>[F:19][C:15]1[CH:14]=[C:13]([C:12]2[C:3]3[C:2](=[C:9]([O:10][CH3:11])[CH:8]=[C:5]([C:6]#[N:7])[CH:4]=3)[NH:23][N:22]=2)[CH:18]=[CH:17][CH:16]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 22260967HCID 22260967、化合物

生成物 1

HCID 222608863-(3-fluorophenyl)-7-methoxy-1H-indazole-5-carbonitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

To a solution of 640 mg of 4-fluoro-3-(3-fluorobenzoyl)-5-methoxybenzonitrile in 6 ml ethanol was added 3 ml of hydrazine monohydrate at room temperature, followed by stirring at 70° C. for one day. The reaction mixture was evaporated, and the resulting crystals were collected by filtration. The crystals were sequentially washed with ethanol and diethyl ether, to give 590 mg of the title compound as colorless crystals.

後処理

  1. customThe reaction mixture was evaporated
  2. filtrationthe resulting crystals were collected by filtration
  3. washThe crystals were sequentially washed with ethanol and diethyl ether

出典と根拠

ORDレコード
ord-250081b3cc5f44099dcb857d0de86e3a
出典データセット
uspto-grants-2010_08
特許番号
US07776890B2

反応ノート

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