2-Aminobenzyl alcohol → (2-Aminobenzyl)triphenylphosphonium bromide

HRID 503366

反応式

HRID 503366 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4]O.[BrH:10].[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(#N)C>[Br-:10].[C:24]1([P+:17]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=2[NH2:1])[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

参加物

4

反応物 2

HCID 214392-Aminobenzyl alcoholHCID 80811Triphenylphosphonium bromide

生成物 1

HCID 10961315(2-Aminobenzyl)triphenylphosphonium bromide収率 88.4%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-Aminobenzyl alcohol (60.0 g, 0.487 mol) was dissolved in acetonitrile (2.5 L) and brought to reflux. Triphenylphosphine hydrobromide (167 g, 0.487 mol) was added and the mixture was heated at reflux for 3 h. The reaction mixture was concentrated to approximately 500 mL and left at room temperature for 1 h. The precipitate was filtered and washed with cold acetonitrile followed by hexane. The solid was dried overnight at 40° C. under vacuum to give triphenyl(2-aminobenzyl)phosphonium bromide (193 g, 88%).

後処理

  1. temperatureto reflux
  2. temperaturethe mixture was heated
  3. temperatureat reflux for 3 h
  4. concentrationThe reaction mixture was concentrated to approximately 500 mL
  5. filtrationThe precipitate was filtered
  6. washwashed with cold acetonitrile
  7. customThe solid was dried overnight at 40° C. under vacuum

出典と根拠

ORDレコード
ord-227b4532e15549158b6b7ee3e1fc86ec
出典データセット
uspto-grants-2010_08
特許番号
US07776905B2

関連ノート

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