Imidazo(1,2-a)pyrazine → 5,6,7,8-Tetrahydroimidazo(1,2-a)pyrazine
反応式
[N:1]1[CH:2]=[CH:3][N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12>[Pd].Cl.CCO>[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12参加物
4
実験手順
Imidazo[1,2-a]pyrazine (250 mg, 2.1 mmol) and palladium on carbon (10%) (55.8 mg, 0.53 mmol) were placed in a pressure resistant bottle and suspended under nitrogen in 0.5M HCl/EtOH. The mixture was stirred under at 45 psi H2 for 16 hrs. LC/MS showed completion. The next day, the reaction mixture was passed through celite cake. The filtrate was concentrated under reduced pressure to afford a tan solid. This was used directly without further purification. MS: [N+H]=124.2; Calc'd for C6H9N3: 123.2.
後処理
- concentrationThe filtrate was concentrated under reduced pressure
- customto afford a tan solid
- customThis was used directly without further purification
出典と根拠
- ORDレコード
- ord-d028f66ec0fa44e58cbc0fca3f1951d4
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07776857B2
反応ノート
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