Hydrochloric Acid → HCID 24861656、化合物

HRID 503656ノート

反応式

HRID 503656 の反応式
[OH:1][CH:2]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([OH:38])[CH:33]=1)[C:3]([NH:5][NH:6][C:7](=[O:31])[C:8]1[C:13]([O:14]CC2C=CC=CC=2)=[CH:12][C:11]([O:22]CC2C=CC=CC=2)=[CH:10][C:9]=1[Cl:30])=[O:4].Cl>C1COCC1>[OH:1][CH:2]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([OH:38])[CH:33]=1)[C:3]([NH:5][NH:6][C:7](=[O:31])[C:8]1[C:13]([OH:14])=[CH:12][C:11]([OH:22])=[CH:10][C:9]=1[Cl:30])=[O:4]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 57857230HCID 57857230、化合物

生成物 1

HCID 24861656HCID 24861656、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

720 mg of N′-[2-hydroxy-2-(3-hydroxyphenyl)acetyl]-2-chloro-4,6-dibenzyloxybenzohydrazide in 20 ml of THF+0.2 ml of 32% HCl are hydrogenated with the calculated amount of H2 using 360 mg of PdoC. The hydrogenation solution is evaporated and chromatographed on silica gel. The uniform fractions are combined, evaporated and recrystallised from EtOAc. Yield 310 mg (65%) of “A15”, m.p. 230-231°.

後処理

  1. customThe hydrogenation solution is evaporated
  2. customchromatographed on silica gel
  3. customevaporated
  4. customrecrystallised from EtOAc

出典と根拠

ORDレコード
ord-e64e2c6f095647f6b5861e9b05bec565
出典データセット
uspto-grants-2010_08
特許番号
US07776920B2

反応ノート

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