4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde → 1-[4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)phenyl]ethanol

HRID 503745

反応式

HRID 503745 の反応式
[C:1]1([C:7]2[C:8]([C:16]3[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:24][Zn]Cl>C1COCC1>[C:1]1([C:7]2[C:8]([C:16]3[CH:17]=[CH:18][C:19]([CH:20]([OH:21])[CH3:24])=[CH:22][CH:23]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 866306554-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehydeHCID 178477798HCID 178477798、化合物

生成物 1

HCID 684592251-[4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)phenyl]ethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
100 °C

実験手順

100 mg 4-(6-phenylimidazo[1,2-a]pyrimidin-7-yl)benzaldehyde (prepared as described for example 1) are dissolved in 2 ml THF and 1 ml of a 2M solution of MeZnCl is added. The mixture is heated (100° C., microwave) for 2 h, cooled to room temperature and extracted with a mixture of dichloromethane and water. The organic layers are dried over sodium sulphate and the solvent is evaporated.

後処理

  1. temperaturecooled to room temperature
  2. extractionextracted with a mixture of dichloromethane and water
  3. dry with materialThe organic layers are dried over sodium sulphate
  4. customthe solvent is evaporated

出典と根拠

ORDレコード
ord-16340b00995b4d2ab54bd087e58b4918
出典データセット
uspto-grants-2010_08
特許番号
US07776864B2

関連ノート

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