2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid tert-butyl ester → 2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

HRID 503884ノート

反応式

HRID 503884 の反応式
C([O:5][C:6](=[O:22])[CH2:7][N:8]1[C:12]2=[N:13][CH:14]=[CH:15][CH:16]=[C:11]2[C:10]([C:17]2[NH:18][CH:19]=[CH:20][N:21]=2)=[N:9]1)(C)(C)C>FC(F)(F)C(O)=O>[NH:21]1[CH:20]=[CH:19][N:18]=[C:17]1[C:10]1[C:11]2[C:12](=[N:13][CH:14]=[CH:15][CH:16]=2)[N:8]([CH2:7][C:6]([OH:22])=[O:5])[N:9]=1

参加物

3

反応物 1

HCID 1363829312-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid tert-butyl ester

生成物 1

HCID 1361746462-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid tert-butyl ester (977 Mg) was dissolved in trifluoroacetic acid (TFA) (10 mL) and stirred at room temperature for 1 hr. The mixture was evaporated in vacuo to provide 2-(3-(1H-imidazol-2-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetic acid as a brown oil, which was used without further purification.

後処理

  1. customThe mixture was evaporated in vacuo

出典と根拠

ORDレコード
ord-bf37f435f4fd453aac591256e671b3db
出典データセット
uspto-grants-2010_08
特許番号
US07777035B2

反応ノート

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