Pyrrolidine → Ethyl 1-(6-pyrrolidin-1-ylpyridin-3-yl)cyclopropanecarboxylate
反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1>>[N:16]1([C:2]2[N:7]=[CH:6][C:5]([C:8]3([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:10][CH2:9]3)=[CH:4][CH:3]=2)[CH2:20][CH2:19][CH2:18][CH2:17]1参加物
3
反応条件
- 温度
- 100 °C
実験手順
A mixture of ethyl 1-(6-chloropyridin-3-yl)cyclopropanecarboxylate (69.8 mg, 0.309 mmol) and pyrrolidine (250.0 μL, 3.0 mmol) in a sealed tube was heated at 100° C. for 4 hours. Then the excess pyrrolidine in the mixture was removed under reduced pressure. The residue was purified by flash chromatography column to afford ethyl 1-(6-pyrrolidin-1-ylpyridin-3-yl)cyclopropanecarboxylate.
後処理
- customThen the excess pyrrolidine in the mixture was removed under reduced pressure
- customThe residue was purified by flash chromatography column
出典と根拠
- ORDレコード
- ord-a3b10b9529da48c18b18d98bee56441e
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07776874B2
反応ノート
読み込み中…