1-Bromo-2-Chloroethane → 1-(4-Vinylphenyl)cyclopropanecarbonitrile
反応式
[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]#[N:11])=[CH:5][CH:4]=1)=[CH2:2].Br[CH2:13][CH2:14]Cl>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.[OH-].[Na+].O>[CH:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:10]#[N:11])[CH2:14][CH2:13]2)=[CH:5][CH:4]=1)=[CH2:2]参加物
6
反応条件
- 温度
- 70 °C
実験手順
A mixture of (4-vinylphenyl)acetonitrile (2.1 g, 0.015 mol), 1-bromo-2-chloro-ethane (1.4 mL, 0.016 mol) and benzyltriethylammonium chloride (0.2 g, 0.0008 mol) in aqueous sodium hydroxide solution (20 m, 6 mL) was stirred at 70° C. for 1 h. The reaction mixture was cooled, diluted with water and extracted with ethyl ether. The combined ether layers were washed with water and brine, dried and concentrated to afford the product.
後処理
- temperatureThe reaction mixture was cooled
- extractionextracted with ethyl ether
- washThe combined ether layers were washed with water and brine
- customdried
- concentrationconcentrated
- customto afford the product
出典と根拠
- ORDレコード
- ord-e07ed7f6a19d48b0b639df4a461bf8be
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07776874B2
反応ノート
読み込み中…