Borane → HCID 66662523、化合物
反応式
B.[C:2]1([C@H:8]2[CH2:12][CH2:11][NH:10][C@@H:9]2[C:13](O)=[O:14])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O1CCCC1>[C:2]1([C@H:8]2[CH2:12][CH2:11][NH:10][C@@H:9]2[CH2:13][OH:14])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
Borane in tetrahydrofuran (1.0 M, 1.0 mL) was added to (2S,3R)-3-phenylpyrrolidine-2-carboxylic acid (30.0 mg, 0.000157 mol) in tetrahydrofuran (1.0 mL, 0.012 mol) at rt. After stirring for 1 h the solvent was evaporated under reduced pressure and the residue was azeotroped with methanol (3×2 mL) to afford the desired product, which was directly used in next step reaction without further purification.
後処理
- customwas evaporated under reduced pressure
- customthe residue was azeotroped with methanol (3×2 mL)
出典と根拠
- ORDレコード
- ord-356abdc803294caf8fd2a99b66c8cda9
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07776874B2
反応ノート
読み込み中…