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4'-[2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-5-chloro-phenyl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione → 6-chloro-4'-[5-chloro-2-(4-piperidinyloxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 504468
ノート
印刷プレビュー

反応式

HRID 504468 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[CH:22]2[CH2:27][C:26](=[O:28])[NH:25][CH:24]([C:29]3[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:30]=3[CH3:36])[C:23]32[C:44]2[C:39](=[CH:40][C:41]([Cl:45])=[CH:42][CH:43]=2)[NH:38][C:37]3=[O:46])[CH2:10][CH2:9]1)=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[Cl:45][C:41]1[CH:40]=[C:39]2[NH:38][C:37](=[O:46])[C:23]3([CH:22]([C:16]4[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=4[O:14][CH:11]4[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]4)[CH2:27][C:26](=[O:28])[NH:25][CH:24]3[C:29]3[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:30]=3[CH3:36])[C:44]2=[CH:43][CH:42]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 1

HCID 749285074'-[2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-5-chloro-phenyl]-6-chloro-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

生成物 1

HCID 749287696-chloro-4'-[5-chloro-2-(4-piperidinyloxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione収率 105.5%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 6422Trifluoroacetic acid
溶媒

実験手順

A solution of racemic (2′S,3S,4′R)-4′-[2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)-5-chloro-phenyl]-6-chloro-2′-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3′-piperidine]-2,6′(1H)-dione (0.7 g, 1 mmol) in TFA (10 mL) was stirred at r.t. for 0.5 h. The solution was diluted with DCM, washed with 1N Na2CO3 aq. (50 mL) and brine (50 mL), dried over anhydrous Na2SO4, concentrated to give title compound as a yellow solid (Yield: 0.6 g).

後処理

  1. washwashed with 1N Na2CO3 aq. (50 mL) and brine (50 mL)
  2. dry with materialdried over anhydrous Na2SO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-6b55f4d974e64fd19ebddca312d0b6fc
出典データセット
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07776875B2

反応ノート

読み込み中…

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