2-(4-Chloro-2-[1,3]dioxolan-2-yl-phenoxy)-2-propyl pentanoic acid ethyl ester → HCID 59428102、化合物

HRID 504584ノート

反応式

HRID 504584 の反応式
[CH2:1]([O:3][C:4](=[O:25])[C:5]([O:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH:20]1OCC[O:21]1)([CH2:9][CH2:10][CH3:11])[CH2:6][CH2:7][CH3:8])[CH3:2]>C(O)(C(F)(F)F)=O>[CH2:1]([O:3][C:4](=[O:25])[C:5]([O:12][C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH:20]=[O:21])([CH2:9][CH2:10][CH3:11])[CH2:6][CH2:7][CH3:8])[CH3:2]

参加物

3

反応物 1

HCID 594280792-(4-Chloro-2-[1,3]dioxolan-2-yl-phenoxy)-2-propyl pentanoic acid ethyl ester

生成物 1

HCID 59428102HCID 59428102、化合物収率 102%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

A solution of 2-(4-chloro-2-[1,3]dioxolan-2-yl-phenoxy)-2-propyl-pentanoic acid ethyl ester (15 g, 42 mmol) in TFA (30 mL) was stirred at room temperature overnight. Then the mixture was concentrated and the residue was partitioned between EtOAc and water. The organic layer was washed with NaOH solution (1 N), water, dried over anhydrous Na2SO4 and concentrated to give the title compound (14 g).

後処理

  1. concentrationThen the mixture was concentrated
  2. customthe residue was partitioned between EtOAc and water
  3. washThe organic layer was washed with NaOH solution (1 N), water
  4. dry with materialdried over anhydrous Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-bde91a10c38a42538936366ad542340c
出典データセット
uspto-grants-2010_08
特許番号
US07776875B2

反応ノート

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