Methanol → HCID 131728297、化合物

反応式

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][S:12]([CH3:14])=[O:13])=[C:6]([CH:9]=1)[CH:7]=O.[Cl:15][C:16]1[CH:24]=[C:23]2[C:19]([CH2:20][C:21](=[O:25])[NH:22]2)=[CH:18][CH:17]=1.N1CCCC1.C[OH:32]>>[Cl:15][C:16]1[CH:24]=[C:23]2[C:19](/[C:20](=[CH:7]/[C:6]3[CH:9]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[O:10][CH2:11][S:12]([CH3:14])(=[O:32])=[O:13])/[C:21](=[O:25])[NH:22]2)=[CH:18][CH:17]=1

参加物

反応物 4

HCID 887Methanol

HCID 31268Pyrrolidine

HCID 7363446-Chloro-1,3-dihydroindol-2-one

HCID 57750215HCID 57750215、化合物

生成物 1

HCID 131728297HCID 131728297、化合物

実験手順

In a manner similar to the method described in Example 9b, 5-chloro-2-methanesulfinylmethoxy-benzaldehyde (1.25 g, 5 mmol) was reacted with 6-chlorooxindole (0.9 g, 5.4 mmol) and pyrrolidine (0.5 mL, 6.1 mmol) in methanol (50 mL) to give the title compound as a yellow solid (1.8 g).