Dimethylformamide → 2-(2-(2-(3-Nitrophenoxy)ethoxy)ethoxy)ethanol

HRID 5048

反応式

HRID 5048 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:23][CH2:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][OH:31]>O.C(OCC)(=O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:7]=[CH:8][CH:9]=1)[O:10][CH2:23][CH2:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30][OH:31])([O-:3])=[O:2]

参加物

7

反応物 4

HCID 6228DimethylformamideHCID 111373-NitrophenolHCID 11430Potassium CarbonateHCID 788712-(2-(2-Chloroethoxy)ethoxy)ethanol

生成物 1

HCID 197977512-(2-(2-(3-Nitrophenoxy)ethoxy)ethoxy)ethanol

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

While stirring a mixture of 27.8 g of m-nitrophenol, 120 ml of N,N-dimethylformamide, and 25 g of potassium carbonate at 80° C., 37 g of 2-(2-(2-chloroethoxy)ethoxy)-ethanol was added dropwise to the mixture. After stirring the mixture for one hour at 80° C., 200 ml of ethyl acetate and 200 ml of water were added to the reaction mixture and the ethyl acetate layer was extracted. The ethyl acetate layer was washed with 200 ml of water and concentrated to remove ethyl acetate to provide 2-(2-(2-(3-nitrophenoxy)ethoxy)ethoxy)ethanol (1-A).

後処理

  1. stirringAfter stirring the mixture for one hour at 80° C.
  2. extractionthe ethyl acetate layer was extracted
  3. washThe ethyl acetate layer was washed with 200 ml of water
  4. concentrationconcentrated
  5. customto remove ethyl acetate

出典と根拠

ORDレコード
ord-90395268b2774bc9b14694b06a459c4d
出典データセット
uspto-grants-1993_09
特許番号
US05243004

関連ノート

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