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Hydrochloric Acid → [1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

HRID 505187
ノート
印刷プレビュー

反応式

HRID 505187 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=4[F:25])[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[H-].[Na+].C(OC([N:35]1[CH2:39][CH2:38]OS1(=O)=O)=O)(C)(C)C.Cl>CN(C=O)C.O>[NH2:35][CH2:39][CH2:38][N:8]1[C:9]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:10]=2)[C:6]([C:11]([N:13]2[CH2:18][CH2:17][N:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])[CH2:15][CH2:14]2)=[O:12])=[CH:7]1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 24758Sodium hydrideHCID 16061731(6-Chloro-1H-indol-3-yl)[4-(2-fluorophenyl)piperazin-1-yl]methanoneHCID 235840203-Boc-1,2,3-oxathiazolidine 2,2-dioxide

生成物 1

HCID 16061732[1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

試薬・触媒・溶媒 2

HCID 962
Water
触媒
HCID 6228Dimethylformamide溶媒

反応条件

温度
0 °C

実験手順

To a solution of (6-chloro-1H-indol-3-yl)-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone in dry DMF under argon at 0° C. was added (1.1 eq) NaH. The reaction mixture was stirred for 1 h at 0° C. 2,2-Dioxo-2λ6-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester (1.1 eq) (described in WO 2003037327) was added, and the reaction mixture was stirred for 2 h at RT. After evaporation of DMF, redissolution in dioxan, addition of 5 eq. of HCl (4.0M solution in dioxane) and a few drops of water, the reaction mixture was stirred for 2 h at 50° C.; LC-MS showed complete conversion to the crude product.

後処理

  1. stirringthe reaction mixture was stirred for 2 h at RT
  2. customAfter evaporation of DMF, redissolution in dioxan
  3. stirringthe reaction mixture was stirred for 2 h at 50° C.

出典と根拠

ORDレコード
ord-f6c6771a6ae945eda21a936a97ac26bf
出典データセット
uspto-grants-2010_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07781436B2

反応ノート

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