Water → 6-Methoxy-5-methyl-2-nitro-3-pyridinamine

HRID 505381ノート

反応式

HRID 505381 の反応式
[CH3:1][O:2][C:3]1[N:8]=[C:7]([N+:9]([O-:11])=[O:10])[C:6]([NH:12]C(=O)C)=[CH:5][C:4]=1[CH3:16].[OH-].[Na+].O>CO>[CH3:1][O:2][C:3]1[N:8]=[C:7]([N+:9]([O-:11])=[O:10])[C:6]([NH2:12])=[CH:5][C:4]=1[CH3:16]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 59429836N-(6-methoxy-5-methyl-2-nitro-3-pyridinyl)acetamide

生成物 1

HCID 594298446-Methoxy-5-methyl-2-nitro-3-pyridinamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The crude product (1.93 g) of N-(6-methoxy-5-methyl-2-nitro-3-pyridinyl) acetamide was dissolved in methanol (36 ml), 5N sodium hydroxide solution (6 ml) was added, and the reaction mixture was stirred for 15 minutes at room temperature. After water was added to the reaction solution, it was extracted with ethyl acetate and dried over magnesium sulfate, and the solvent was evaporated, thereby yielding the title compound (1.06 g, 5.79 mmol) as a yellow solid.

後処理

  1. extractionwas extracted with ethyl acetate
  2. dry with materialdried over magnesium sulfate
  3. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-7e8cb2b8bc3f4da4a4c933dcf9bf1f6b
出典データセット
uspto-grants-2010_08
特許番号
US07781452B2

反応ノート

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