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3-(p-Tolyl)acrylic acid → (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-phenyl}-2-(3-p-tolylacryloylamino)-propanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(p-Tolyl)acrylic acid | HCID 15835 | — |
| 反応物 | (2S)-2-Amino-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)-ethoxy]-phenyl}-propionic acid methyl ester | HCID 68445645 | — |
| 生成物 | (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-phenyl}-2-(3-p-tolylacryloylamino)-propanoic acid | HCID 68445072 | 24% |
反応手順
Following the procedures described in Example 1, Intermediate 3B was used in place of Intermediate 3A, and 4-methylcinnamic acid was used in place of cinnamic acid to give (2S)-3-{3-bromo-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-phenyl}-2-(3-p-tolylacryloylamino)-propanoic acid as a white solid with the yield of 24% and mp of 243˜245° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07781468B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-a06641ca0bd2486eb8ce7461f79195e1 |
| 出典メモ | uspto-grants-2010_08 |