Methanol → (R)-2-Hydroxy-1-morpholinopropan-1-one

HRID 505674

反応式

HRID 505674 の反応式
[C:1]([O:6]C)(=O)[C@@H:2]([CH3:4])[OH:3].[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.C[O-].[Na+].CO>>[N:8]1([C:1](=[O:6])[C@H:2]([OH:3])[CH3:4])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

参加物

5

反応物 4

HCID 887MethanolHCID 8083MorpholineHCID 637514(+)-Methyl lactateHCID 10942334Sodium Methoxide

生成物 1

HCID 14978393(R)-2-Hydroxy-1-morpholinopropan-1-one

反応条件

温度
50 °C

実験手順

To (R)-methyl lactate (24.42 g, 0.23 mol) were added morphline (21.46 g, 0.25 mol) and sodium methoxide in methanol (14%, 9.04 g, 0.02 mol) and the mixture was stirred for 3 hours at 50° C. After removal of the solvent in vacuo, the residue was subjected to azeotropic distillation three times with toluene to give the subject compound (quant.).

後処理

  1. customAfter removal of the solvent in vacuo
  2. distillationthe residue was subjected to azeotropic distillation three times with toluene
  3. customto give the subject compound (quant.)

出典と根拠

ORDレコード
ord-e707a0c4b0174d8e9cf946366f8c997f
出典データセット
uspto-grants-2010_08
特許番号
US07781479B2

関連ノート

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