関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | (+)-Methyl lactate | HCID 637514 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 生成物 | (R)-2-Hydroxy-1-morpholinopropan-1-one | HCID 14978393 | — |
反応手順
To (R)-methyl lactate (24.42 g, 0.23 mol) were added morphline (21.46 g, 0.25 mol) and sodium methoxide in methanol (14%, 9.04 g, 0.02 mol) and the mixture was stirred for 3 hours at 50° C. After removal of the solvent in vacuo, the residue was subjected to azeotropic distillation three times with toluene to give the subject compound (quant.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07781479B2 |
|---|
| 出典データセット | uspto-grants-2010_08 |
|---|
| ORD ID | ord-e707a0c4b0174d8e9cf946366f8c997f |
|---|
| 出典メモ | uspto-grants-2010_08 |
|---|
