Hydrochloric Acid → 4-Hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride

HRID 505697ノート

反応式

HRID 505697 の反応式
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH2:10][O:11][CH3:12])[CH:3]=1.O.[NH2:14][NH2:15].C(O)C.[ClH:19]>CO.C(OCC)C>[ClH:19].[NH:14]([C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([CH2:10][O:11][CH3:12])[CH:3]=1)[NH2:15]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 594293094-Fluoro-2-(methoxymethyl)benzonitrile

生成物 1

HCID 469151914-Hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 4-fluoro-2-(methoxymethyl)benzonitrile (110 mg, 0.67 mmol), hydrazine monohydrate (133 mg, 0.13 mL, 2.6 mmol) and ethanol (5 mL) was heated to reflux overnight. The mixture was cooled to room temp and condensed. The residue was dissolved in methanol and treated with 2.0 N Hydrogen chloride in diethyl ether. The solvent was removed and the solid was dried to give 4-hydrazinyl-2-(methoxymethyl)benzonitrile hydrochloride as an off-white solid.

後処理

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customcondensed
  4. customThe solvent was removed
  5. customthe solid was dried

出典と根拠

ORDレコード
ord-6b1498ae6dcc4bf6858cdda7915a81dd
出典データセット
uspto-grants-2010_08
特許番号
US07781428B2

反応ノート

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