6-(cyclohex-1-enyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid → 6-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid

HRID 505807ノート

反応式

HRID 505807 の反応式
[C:1]1([C:7]2[C:8]3[S:14][C:13]([C:15]([OH:17])=[O:16])=[CH:12][C:9]=3[NH:10][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.[H][H]>CO.CCOC(C)=O.[OH-].[OH-].[Pd+2]>[CH:1]1([C:7]2[C:8]3[S:14][C:13]([C:15]([OH:17])=[O:16])=[CH:12][C:9]=3[NH:10][CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

5

反応物 2

HCID 586790836-(cyclohex-1-enyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 586790966-cyclohexyl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid収率 98%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 21584119Ethylacetate methanol溶媒

実験手順

A solution (0.1 M) of 6-cyclohex-1-en-1-yl-4H-thieno[3,2-b]pyrrole-2-carboxylic acid in MeOH/AcOEt (2:1) was treated with 20% Pd(OH)2/C (10% wt.). The resulting suspension was stirred for 18 h under 45 psi of hydrogen then purged with nitrogen and filtered. The filtrate was concentrated to afford the title compound (98%) as a solid.

後処理

  1. customthen purged with nitrogen
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-f5c7bcc51b6e4a439a896d179c06b6b8
出典データセット
uspto-grants-2010_08
特許番号
US07781431B2

反応ノート

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