Methanol → 9-Ethyl-9H-carbazole-3-carboxylic acid

HRID 50609

反応式

HRID 50609 の反応式
[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]([CH:16]=[O:17])=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH3:2].[Mn]([O-])(=O)(=O)=[O:19].[K+].CO>CC(C)=O>[CH2:1]([N:3]1[C:15]2[CH:14]=[CH:13][C:12]([C:16]([OH:19])=[O:17])=[CH:11][C:10]=2[C:9]2[C:4]1=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH3:2]

参加物

5

反応物 3

HCID 887MethanolHCID 820559-ethyl-9H-carbazole-3-carbaldehydeHCID 516875Potassium Permanganate

生成物 1

HCID 49128699-Ethyl-9H-carbazole-3-carboxylic acid収率 61.6%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

50 g of N-ethylcarbazole-3-carboxaldehyde was dissolved in 1 L of acetone, and the solution was added with 70.6 g of potassium permanganate under ice cooling, stirred for 3 hours, then added with 100 mL of methanol and filtered. The filtrate was evaporated under reduced pressure, and the residue was dissolved in aqueous sodium hydrogencarbonate. Then, the solution was made acidic by adding concentrated hydrochloric acid, and the deposited precipitates were collected to obtain 33 g of N-ethylcarbazole-3-carboxylic acid.

後処理

  1. filtrationfiltered
  2. customThe filtrate was evaporated under reduced pressure
  3. dissolutionthe residue was dissolved in aqueous sodium hydrogencarbonate
  4. additionby adding concentrated hydrochloric acid
  5. customthe deposited precipitates
  6. customwere collected

出典と根拠

ORDレコード
ord-cd235a0093da40bfaf22543d6aff285a
出典データセット
uspto-grants-2004_03
特許番号
US06713473B1

関連ノート

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