Acetonitrile → 1-Naphthalenesulfonylaminoethylthioethylamine

HRID 50610

反応式

HRID 50610 の反応式
N[CH2:2][CH2:3][S:4][CH2:5][CH2:6][NH2:7].[C:8]1([S:18](Cl)(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1.C(#[N:24])C>>[C:8]1([S:18]([NH:24][CH:3]([S:4][CH2:5][CH2:6][NH2:7])[CH3:2])(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 3

HCID 6342AcetonitrileHCID 665601-Naphthalenesulfonyl chlorideHCID 700962,2'-Thiobis(ethanamine)

生成物 1

HCID 698871031-Naphthalenesulfonylaminoethylthioethylamine

実験手順

Under ice cooling, 5.29 g of aminoethylthioethylamine was added dropwise with 120 mL of acetonitrile solution in which 1.00 g of 1-naphthalenesulfonyl chloride was dissolved, and the mixture was stirred at room temperature for two days. The reaction mixture was evaporated under reduced pressure, and then the residue was added with 500 mL of water and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 1.50 g of 1-naphthalenesulfonylaminoethylthioethylamine.

後処理

  1. dissolutionwas dissolved
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionthe residue was added with 500 mL of water
  4. extractionextracted with dichloromethane
  5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  6. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-85c61463f18548a999ef56fba6e12601
出典データセット
uspto-grants-2004_03
特許番号
US06713473B1

関連ノート

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