Cadaverine → N-(5-aminopentyl)naphthalene-1-sulfonamide

HRID 50611

反応式

HRID 50611 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[C:8]1([S:18](Cl)(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1>C(#N)C>[C:8]1([S:18]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][NH2:7])(=[O:20])=[O:19])[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 273CadaverineHCID 665601-Naphthalenesulfonyl chloride

生成物 1

HCID 4303N-(5-aminopentyl)naphthalene-1-sulfonamide収率 84.2%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Under ice cooling, 7.91 g of 1,5-diaminopentane was added dropwise with 240 mL of acetonitrile solution in which 1.75 g of 1-naphthalenesulfonyl chloride was dissolved, and the mixture was stirred at room temperature for 1 hour. The reaction mixture was evaporated under reduced pressure, and the residue was added with 500 mL of water and extracted with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain 1.90 g of 5-(1-naphthalenesulfonyl)aminopentylamine.

後処理

  1. dissolutionwas dissolved
  2. customThe reaction mixture was evaporated under reduced pressure
  3. additionthe residue was added with 500 mL of water
  4. extractionextracted with dichloromethane
  5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-e8b2e0abf9594c33858deb2304f39cd4
出典データセット
uspto-grants-2004_03
特許番号
US06713473B1

関連ノート

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