Iodine → HCID 178510339、化合物

HRID 506172ノート

反応式

HRID 506172 の反応式
[OH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][CH:3]=1.[I:10]I.[OH-].[Na+]>O>[OH:1][C:2]1[C:7]([C:8]#[N:9])=[CH:6][N:5]=[CH:4][C:3]=1[I:10]

参加物

5

反応物 3

HCID 807IodineHCID 14798Sodium HydroxideHCID 178510337HCID 178510337、化合物

生成物 1

HCID 178510339HCID 178510339、化合物収率 61.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
85 °C

実験手順

A mixture of 4-hydroxynicotinonitrile (45.7 g, 381 mmol), iodine (96.6 g, 381 mmol) and NaOH (19.8 g, 825 mmol) in water (600 mL) was heated at 85° C. overnight, cooled to r.t. and diluted with water. The precipitate was collected by filtration and washed with water to give 57.5 g (61%) of 4-hydroxy-5-iodonicotinonitrile as a tan solid. Mp>245° C.

後処理

  1. temperaturecooled to r.t.
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water

出典と根拠

ORDレコード
ord-a88d4654205b49ecac2b716b56ed3020
出典データセット
uspto-grants-2010_08
特許番号
US07781591B2

反応ノート

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