Lithium Hydroxide → 5-Chloro-2-phenylbenzoxazole-7-carboxylic acid

HRID 506254

反応式

HRID 506254 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:17]([O:19]C)=[O:18])[C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:7][C:6]=2[CH:16]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:17]([OH:19])=[O:18])[C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[N:7][C:6]=2[CH:16]=1

参加物

3

反応物 2

HCID 3939Lithium HydroxideHCID 68454443Methyl 5-chloro-2-phenyl-benzoxazole-7-carboxylate

生成物 1

HCID 684565005-Chloro-2-phenylbenzoxazole-7-carboxylic acid収率 82%

実験手順

5-Chloro-2-phenylbenzoxazole-7-carboxylic acid was prepared from methyl 5-chloro-2-phenyl-benzoxazole-7-carboxylate via lithium hydroxide mediated hydrolysis as described in Step B of Example 14. This material was obtained as a white solid in 82% yield. 1H NMR (300 MHz, DMSO-d6) δ 13.84 (br s, 1H), 8.22-8.19 (m, 3H), 7.85 (d, J=2.1 Hz, 1H), 7.70-7.63 (m, 3H), 4.07 (s, 3H); MS (ESI) m/z 274 [M+H]+.

後処理

  1. customhydrolysis
  2. customThis material was obtained as a white solid in 82% yield

出典と根拠

ORDレコード
ord-945d2baad0494423afb1666aca8cfc33
出典データセット
uspto-grants-2010_08
特許番号
US07781430B2

関連ノート

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