Triethylamine → HCID 59432150、化合物

HRID 506489

反応式

HRID 506489 の反応式
[NH2:1][CH:2]([CH:8]([OH:13])[C:9]([F:12])([F:11])[F:10])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[F:14][C:15]1[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[C:17]([C:24]([F:27])([F:26])[F:25])[CH:16]=1.C(N(CC)CC)C>C1COCC1>[F:12][C:9]([F:10])([F:11])[CH:8]([OH:13])[CH:2]([NH:1][C:19](=[O:20])[C:18]1[CH:22]=[CH:23][C:15]([F:14])=[CH:16][C:17]=1[C:24]([F:27])([F:25])[F:26])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 6882554-Fluoro-2-(trifluoromethyl)benzoic acidHCID 15634552HCID 15634552、化合物

生成物 1

HCID 59432150HCID 59432150、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.7 g (8.5 mmol) of ethyl 2-amino-4,4,4-trifluoro-3-hydroxybutyrate were dissolved in THF, and initially 1.8 g of 4-fluoro-2-trifluoromethylbenzoic acid and 2.6 g (25.4 mmol) of triethylamine and then, at 5° C., 1.9 g (8.5 mmol) of bis(2-oxo-3-oxazolinidylphosphoryl chloride were added. The mixture was stirred at RT for 16 h. The reaction solution was then concentrated, and the residue was diluted with water and extracted with ethyl acetate. The combined organic phases were dried and the solvent was removed. This gave 3.1 g (93% of theory) of the title compound as a colorless residue.

後処理

  1. concentrationThe reaction solution was then concentrated
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate
  4. customThe combined organic phases were dried
  5. customthe solvent was removed

出典と根拠

ORDレコード
ord-a1eb04bf736d47c4a21d42c4c66297f6
出典データセット
uspto-grants-2010_08
特許番号
US07786046B2

関連ノート

読み込み中…