HCID 13292919、化合物 → HCID 178452909、化合物

HRID 506587ノート

反応式

HRID 506587 の反応式
[C:1]1([C:7]2[NH:16][C:10]3=[N:11][CH:12]=[C:13]([NH2:15])[CH:14]=[C:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:18]([O:20][CH:21]([CH:23]=[CH2:24])[CH3:22])=[O:19]>N1C=CC=CC=1.ClCCl.O>[CH3:22][CH:21]([O:20][C:18](=[O:19])[NH:15][C:13]1[CH:14]=[C:9]2[N:8]=[C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[NH:16][C:10]2=[N:11][CH:12]=1)[CH:23]=[CH2:24]

参加物

6

反応物 2

HCID 13292919HCID 13292919、化合物HCID 178508009HCID 178508009、化合物

生成物 1

HCID 178452909HCID 178452909、化合物

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

80 mg 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine (0.38 mmol,) in 3 ml dry pyridine were treated with a solution of 3-buten-2-yl chloroformate in dichloromethane. The mixture was stirred at room temperature over night, diluted with 1 ml water and stirred for another hr. The solvents were evaporated and the residue was dispersed in water with sonication, filtered, and the filter residue washed thoroughly with water and ether.

後処理

  1. stirringstirred for another hr
  2. customThe solvents were evaporated
  3. additionthe residue was dispersed in water with sonication
  4. filtrationfiltered
  5. washthe filter residue washed thoroughly with water and ether

出典と根拠

ORDレコード
ord-fc08b83e49d7436fb938071f3c630d09
出典データセット
uspto-grants-2010_08
特許番号
US07786113B2

反応ノート

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