Water → HCID 178447164、化合物

HRID 506588ノート

反応式

HRID 506588 の反応式
[CH3:1][CH:2]([OH:6])[CH:3]=[CH:4][CH3:5].[C:7](N1C=CN=C1)(N1C=CN=C1)=[O:8].[C:19]1([C:25]2[NH:34][C:28]3=[N:29][CH:30]=[C:31]([NH2:33])[CH:32]=[C:27]3[N:26]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>ClCCl.CN1CCCC1=O>[CH3:1][CH:2]([O:6][C:7](=[O:8])[NH:33][C:31]1[CH:32]=[C:27]2[N:26]=[C:25]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[NH:34][C:28]2=[N:29][CH:30]=1)/[CH:3]=[CH:4]/[CH3:5]

参加物

7

反応物 4

HCID 962WaterHCID 15289(+-)-3-Penten-2-olHCID 682631,1'-CarbonyldiimidazoleHCID 178508009HCID 178508009、化合物

生成物 1

HCID 178447164HCID 178447164、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
0 °C

実験手順

32 mg 3-penten-2-ol (0.38 mmol,) in 1 ml dry dichloromethane were treated at 0° C. with 62 mg 1,1′-carbonyl-diimidazole. The mixture was stirred at 0° C. for 2 hrs. 80 mg 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine (0.38 mmol,) in 0.5 ml N-methylpyrrolidone (NMP) were added and the mixture stirred over night at room temperature. 1 ml water was added, the precipitate filtered, and the filter residue washed thoroughly with water and ether and further purified by chromatography.

後処理

  1. stirringthe mixture stirred over night at room temperature
  2. filtrationthe precipitate filtered
  3. washthe filter residue washed thoroughly with water and ether
  4. customfurther purified by chromatography

出典と根拠

ORDレコード
ord-41505af1f0fc4283913024858fe5251c
出典データセット
uspto-grants-2010_08
特許番号
US07786113B2

反応ノート

読み込み中…