Sodium Hydroxide → HCID 178503121、化合物

HRID 506591

反応式

HRID 506591 の反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([N+:9]([O-:11])=[O:10])=[CH:4][N:3]=1.[CH3:12][S:13][C:14]1[CH:22]=[CH:21][C:17]([C:18](O)=O)=[CH:16][CH:15]=1.[OH-].[Na+]>O>[CH3:12][S:13][C:14]1[CH:22]=[CH:21][C:17]([C:18]2[NH:1][C:2]3=[N:3][CH:4]=[C:5]([N+:9]([O-:11])=[O:10])[CH:6]=[C:7]3[N:8]=2)=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 832304-(Methylthio)benzoic acidHCID 34801515-Nitropyridine-2,3-diamine

生成物 1

HCID 178503121HCID 178503121、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.0 g 2,3-diamino-5-nitropyridine and 1.125 g 4-methylsulfanylbenzoic acid in 20 ml polyphosphoric acid were heated to 160° C. with stirring for 15 hrs. The mixture was cooled and poured into water. The pH was adjusted to 4-5 by addition of sodium hydroxide and the precipitate collected by filtration. The filtration residue was stirred in 50 ml pyridine at 60° C., cooled and insoluble components removed by filtration. The filtrate was evaporated and the residue used without further purification in the next steps.

後処理

  1. temperatureThe mixture was cooled
  2. filtrationthe precipitate collected by filtration
  3. stirringThe filtration residue was stirred in 50 ml pyridine at 60° C.
  4. temperaturecooled
  5. custominsoluble components removed by filtration
  6. customThe filtrate was evaporated
  7. customthe residue used without further purification in the next steps

出典と根拠

ORDレコード
ord-8474e7643ba740139fd5909dc95249b9
出典データセット
uspto-grants-2010_08
特許番号
US07786113B2

関連ノート

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