Bromine → 5-Bromo-4-isopropylthiazol-2-amine

HRID 506624

反応式

HRID 506624 の反応式
[CH:1]([C:4]1[N:5]=[C:6]([NH2:9])[S:7][CH:8]=1)([CH3:3])[CH3:2].[Br:10]Br.C([O-])(O)=O.[Na+]>C(Cl)(Cl)Cl>[Br:10][C:8]1[S:7][C:6]([NH2:9])=[N:5][C:4]=1[CH:1]([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 24408BromineHCID 516892Sodium BicarbonateHCID 70640774-(Propan-2-yl)-1,3-thiazol-2-amine

生成物 1

HCID 534881395-Bromo-4-isopropylthiazol-2-amine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

A solution of 4-isopropyl-thiazol-2-ylamine (2.0 g, 14 mmol) in 30 mL CHCl3 was added dropwise to a stirring solution of bromine ((2.697 g, 17 mmol) in 15 mL CHCl3. The reaction mixture was stirred for 60 hours at room temperature. The reaction mixture was poured into saturated aqueous NaHCO3, and extracted with methylene chloride. The combined organic extracts were washed with saturated aqueous NaHCO3 and brine, dried (MgSO4), filtered and concentrated under reduced pressure to give 2.05 g of 5-bromo-4-isopropyl-thiazol-2-ylamine as an oil.

後処理

  1. extractionextracted with methylene chloride
  2. washThe combined organic extracts were washed with saturated aqueous NaHCO3 and brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-8ce79d5f437e49689190bcb2f29b2e24
出典データセット
uspto-grants-2010_08
特許番号
US07786110B2

関連ノート

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