Brofoxine → 6-(4-Chlorophenyl)-4,4-dimethyl-1H-benzo[D][1,3]oxazin-2(4H)-one

関与物質

役割	名称	HCID	仕込み量
反応物	Brofoxine	HCID 30630	—
反応物	4-Chlorophenylboronic acid	HCID 74299	—
生成物	6-(4-Chlorophenyl)-4,4-dimethyl-1H-benzo[D][1,3]oxazin-2(4H)-one	HCID 9795931	—

反応手順

Prepared according to Procedure A from 6-bromo-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one and 4-chlorophenyl boronic acid. White solid: mp 255-257° C.; 1H-NMR (DMSO-d6) δ 10.3 (s, 1H), 7.7 (d, 2H, J=8.52 Hz), 7.55 (m, 2H), 7.5 (d, 2H, J=8.52 Hz), 6.96 (d, 1H, J=8.52 Hz), 1.7 (s, 6H); MS (ESI) m/z 288 ([M+H]+, 70%); Anal. Calc. For C16H14ClNO2: C, 66.79; H, 4.90; N, 4.87. Found: C, 66.34; H, 4.76; N, 4.75.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US06713478B2
出典データセット	uspto-grants-2004_03
ORD ID	ord-eec6917e10204cedaeee5696f8a11ea1
出典メモ	uspto-grants-2004_03