7-benzyloxy-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one → 7-hydroxy-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

HRID 506742ノート

反応式

HRID 506742 の反応式
C([O:8][C:9]1[CH:21]=[C:20]2[C:12]([N:13]3[C:18](=[CH:19]2)[C:17](=[O:22])[NH:16][CH2:15][CH2:14]3)=[N:11][CH:10]=1)C1C=CC=CC=1>[Pd].C(O)=O>[OH:8][C:9]1[CH:21]=[C:20]2[C:12]([N:13]3[C:18](=[CH:19]2)[C:17](=[O:22])[NH:16][CH2:15][CH2:14]3)=[N:11][CH:10]=1

参加物

4

反応物 1

HCID 684655717-benzyloxy-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

生成物 1

HCID 684640317-hydroxy-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

試薬・触媒・溶媒 2

HCID 23938Palladium触媒2 回HCID 284Formic Acid溶媒

実験手順

The suspension consistent of 0.20 g (0.68 mmol) 7-benzyloxy-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one and 30 μg palladium on activated charcoal (10% Pd; commercially available) in 2 mL formic acid was hydrogenated at room temperature at 1.5 bar for 3 hours. The reaction mixture was filtered over Dicalite Speed Plus® (Aldrich), the filter cake was washed with formic acid and the volatile components were evaporated at a rotary evaporator. The residue was stirred in 3 mL ethyl acetate, filtered and the light brown product (65%) was dried under high vacuum.

後処理

  1. filtrationThe reaction mixture was filtered over Dicalite
  2. washPlus® (Aldrich), the filter cake was washed with formic acid
  3. customthe volatile components were evaporated at a rotary evaporator
  4. filtrationfiltered
  5. dry with materialthe light brown product (65%) was dried under high vacuum

出典と根拠

ORDレコード
ord-f42ad22fdc46406d94b51bf2e3243b05
出典データセット
uspto-grants-2010_08
特許番号
US07786109B2

反応ノート

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