Water → 2-Bromo-6-iodo-3-methoxypyridine

HRID 506769

反応式

HRID 506769 の反応式
[CH3:1]I.[Br:3][C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([I:11])[N:5]=1.O>CN(C=O)C>[Br:3][C:4]1[C:9]([O:10][CH3:1])=[CH:8][CH:7]=[C:6]([I:11])[N:5]=1

参加物

5

反応物 3

HCID 962WaterHCID 6328Methyl iodideHCID 109794792-Bromo-6-iodopyridin-3-ol2 回

生成物 1

HCID 110990402-Bromo-6-iodo-3-methoxypyridine収率 100%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

Add K2CO2 (6.22 g, 45.1 mmol) and methyl iodide (24.6 g, 10.77 mL, 173.3 mmol) to 2-bromo-6-iodopyridin-3-ol, 2 (14.9 g, 49.5 mmol), dissolved in DMF (30 mL). Heat the reaction medium at 100° C. for 2 h, then leave it to cool to room temperature. Then stop the reaction with H2O and stir it for a further 30 min. The precipitate is then filtered, washed with H2O and dried in air to give 3 (15.7 g, 100%) in solid form, light brown: 1H NMR (CDCl3) δ 7.61 (d, 1H, J=8.4 Hz), 6.86 (d, 1H, J=8.4 Hz), 3.93 (s, 3H); m/z obs.=314 (M+1), 315.

後処理

  1. customleave it
  2. temperatureto cool to room temperature
  3. filtrationThe precipitate is then filtered
  4. washwashed with H2O
  5. customdried in air

出典と根拠

ORDレコード
ord-ac1f9cc4e7ae4f0d859fadbd384831a8
出典データセット
uspto-grants-2010_08
特許番号
US07786114B2

関連ノート

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