Bromine → N-[4-(2-BROMOACETYL)-3-FLUOROPHENYL]acetamide

HRID 507407ノート

反応式

HRID 507407 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=1[F:14])(=[O:3])[CH3:2].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][C:5]=1[F:14])=[O:3]

参加物

4

反応物 2

HCID 24408BromineHCID 14621109N-(4-Acetyl-3-fluorophenyl)acetamide

生成物 1

HCID 86346474N-[4-(2-BROMOACETYL)-3-FLUOROPHENYL]acetamide収率 82.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

N-(4-Acetyl-3-fluoro-phenyl)-acetamide (10.2 g, 51.2 mmol) is dissolved in 50 mL chloroform. At room temperature bromine (1.98 mL, 38.4 mmol) is added drop wise. The reaction mixture is stirred at room temperature for 1.5 hours. Subsequently the precipitated product is filtered off, washed first with chloroform and then with ethyl acetate to yield N-[4-(2-bromo-acetyl)-3-fluoro-phenyl]-acetamide (8.7 g, 43%); LCIMS at 254 nm; [M+H] 275; Rt 2.918 min)

後処理

  1. filtrationSubsequently the precipitated product is filtered off
  2. washwashed first with chloroform

出典と根拠

ORDレコード
ord-36ad943755504f6d9a194d0e76d4286b
出典データセット
uspto-grants-2010_08
特許番号
US07786155B2

反応ノート

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