Sodium Hydroxide → 7-Chloro-1-benzothiophene-2-carboxylic acid

HRID 507694ノート

反応式

HRID 507694 の反応式
[Cl:1][C:2]1[C:7]2[S:8][C:9]([C:11]([O:13]C)=[O:12])=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[C:7]2[S:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22474203Methyl 7-chlorobenzo[b]thiophene-2-carboxylate

生成物 1

HCID 101982427-Chloro-1-benzothiophene-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Methyl 7-chlorobenzo[b]thiophene-2-carboxylate (3 g, 13 mmol) was dissolved is ethanol (15 mL) and treated 5 N sodium hydroxide (5 mL). The reaction was heated at reflux overnight. The volatiles were removed in vacuo and the aqueous residue was acidified to pH 2 using 5 N HCl. The resulting white solid was filtered off, washed well with water and dried in a vacuum oven at 60° C. Yield=2.6 g. MS (M−H)− 210.

後処理

  1. temperatureThe reaction was heated
  2. temperatureat reflux overnight
  3. customThe volatiles were removed in vacuo
  4. filtrationThe resulting white solid was filtered off
  5. washwashed well with water
  6. customdried in a vacuum oven at 60° C

出典と根拠

ORDレコード
ord-fea189dc2932427e8c75b27d77b41223
出典データセット
uspto-grants-2010_08
特許番号
US07786132B2

反応ノート

読み込み中…