[4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)phenyl]methanol → 4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde

HRID 507951ノート

反応式

HRID 507951 の反応式
[C:1]1([CH2:7][CH2:8][C:9]2[N:13]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([CH2:21][OH:22])=[CH:17][CH:16]=3)[N:12]=[C:11]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=3)[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[C:1]1([CH2:7][CH2:8][C:9]2[N:13]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([CH:21]=[O:22])=[CH:17][CH:16]=3)[N:12]=[C:11]([C:23]3[CH:24]=[CH:25][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:28]=3)[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 23157337[4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)phenyl]methanol

生成物 1

HCID 231572154-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)benzaldehyde収率 86%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of [4-({5-(2-phenylethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-yl}methyl)phenyl]methanol (2.00 g, 4.58 mmol), manganese dioxide (7.00 g, 80.5 mmol) and tetrahydrofuran (50 mL) was stirred at room temperature for 2 hr. The insoluble material was filtered off and the filtrate was concentrated to give the title compound (1.70 g, yield 86%) as colorless crystals.

後処理

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-d7ce200f9dd0400aab3efa73f520d0f8
出典データセット
uspto-grants-2010_08
特許番号
US07786165B2

反応ノート

読み込み中…