Water → 7-amino-4-([R]-1-phenylethylamino)pyrido[4,3-d]pyrimidine

HRID 50806

反応式

HRID 50806 の反応式
[C:1]1([C@H:7]([NH2:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][C:11]1[N:20]=[CH:19][C:18]2[C:17](SC)=[N:16][CH:15]=[N:14][C:13]=2[CH:12]=1.O>C(Cl)(Cl)Cl>[NH2:10][C:11]1[N:20]=[CH:19][C:18]2[C:17]([NH:9][C@@H:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH3:8])=[N:16][CH:15]=[N:14][C:13]=2[CH:12]=1

参加物

5

反応物 3

HCID 962WaterHCID 6431891-Phenethylamine, (+)-HCID 104425627-Amino-4-methylthiopyrido[4,3-d]pyrimidine

生成物 1

HCID 539624137-amino-4-([R]-1-phenylethylamino)pyrido[4,3-d]pyrimidine収率 10.9%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
180 °C

実験手順

A mixture of [R]-1-phenylethylamine (0.072 mL, 0.55 mmol) and 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (97 mg, 0.5 mmol) (described in a previous experimental) is heated at 180° C. under N2 for 1.5 hr. The reaction is then cooled to room temperature producing a precipitate. The mixture is added to water and CHCl3, sonicated and filtered. The phases are separated and the aqueous phase is extracted with CHCl3. The combined extracts are washed with water, saturated brine and dried (MgSO4). The solvent is removed under reduced pressure and the residue purified by using preparative tlc (5% MeOH/CHCl3) and recrystallization from CHCl3 to give 7-amino-4-([R]-1-phenylethylamino)pyrido[4,3-d]pyrimidine (14.5 mg, 11), mp 231.8-232.1° C. 1H NMR (DMSO) δ 9.23 (1H, s), 8.50 (1H, d, J=8.0 Hz), 8.19 (1H, s), 7.41 (2H, d, J=7.0 Hz), 7.31 (2H, t, J=8.0 Hz, 7.21 (1H, tt, J=7.4, 1.2 Hz), 6.45 (2H, s), 6.33 (1H, s), 5.56 (1H, p, J=7.2 Hz), 1.55 (3H, d, J=7.0 Hz).

後処理

  1. temperatureThe reaction is then cooled to room temperature
  2. customproducing a precipitate
  3. customsonicated
  4. filtrationfiltered
  5. customThe phases are separated
  6. extractionthe aqueous phase is extracted with CHCl3
  7. washThe combined extracts are washed with water, saturated brine
  8. dry with materialdried (MgSO4)
  9. customThe solvent is removed under reduced pressure
  10. customthe residue purified
  11. customtlc (5% MeOH/CHCl3) and recrystallization from CHCl3

出典と根拠

ORDレコード
ord-8b84da09bf534a59b69c90c8e4b02c51
出典データセット
uspto-grants-2004_03
特許番号
US06713484B2

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