Sulfuric Acid → 4-(Chloromethyl)-2-(4-fluoro-3-methylphenyl)-1,3-oxazole

HRID 508153ノート

反応式

HRID 508153 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[CH3:11].[Cl:12][CH2:13][C:14]([CH2:16]Cl)=O.S(=O)(=O)(O)O>>[Cl:12][CH2:13][C:14]1[N:8]=[C:6]([C:5]2[CH:9]=[CH:10][C:2]([F:1])=[C:3]([CH3:11])[CH:4]=2)[O:7][CH:16]=1

参加物

4

反応物 3

HCID 1118Sulfuric AcidHCID 107931,3-DichloroacetoneHCID 27745784-Fluoro-3-methylbenzamide

生成物 1

HCID 582842534-(Chloromethyl)-2-(4-fluoro-3-methylphenyl)-1,3-oxazole

実験手順

2.00 g (12.80 mmol) of 4-fluoro-3-methylbenzamide and 1.79 g (14.08 mmol) of 1,3-dichloro-acetone are stirred at 130° C. for 2 days. A melt is formed. The mixture is then cooled to RT, 3.0 ml of conc. sulfuric acid are added carefully at this temperature and the mixture is stirred for 15 min. The resulting suspension is poured into 20 ml of ice-water and stirred at RT overnight. The precipitate formed is filtered off and dried at 40° C. in a vacuum drying cabinet overnight.

後処理

  1. customA melt is formed
  2. stirringstirred at RT overnight
  3. customThe precipitate formed
  4. filtrationis filtered off
  5. customdried at 40° C. in a vacuum
  6. customdrying cabinet overnight

出典と根拠

ORDレコード
ord-01901bcf48d84da2958c5005252af0f4
出典データセット
uspto-grants-2015_08
特許番号
US09095582B2

反応ノート

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