Sodium borohydride → HCID 22736932、化合物

HRID 50855ノート

反応式

HRID 50855 の反応式
[BH4-].[Na+].[OH:3][C:4]1([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)[CH2:9][CH2:8][N:7]([CH2:10][C:11]([C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]3)=[O:12])[CH2:6][CH2:5]1>C(O)C>[OH:12][CH:11]([C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18](=[O:23])[CH2:17][CH2:16]2)[CH2:10][N:7]1[CH2:8][CH2:9][C:4]([OH:3])([C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=2)[CH2:5][CH2:6]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 227369406-{[4-Hydroxy-4-(3-methoxyphenyl)-1-piperidinyl]acetyl}-3,4-dihydroquinolin-2(1h)-one

生成物 1

HCID 22736932HCID 22736932、化合物収率 69%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

To a stirred solution of sodium borohydride (1.15 g, 30.3 mmol) in ethanol (100 ml) was added suspension of 6-{[4-Hydroxy-4-(3-methoxyphenyl)-1-piperidinyl]acetyl}-3,4-dihydroquinolin-2(1H)-one (5.98 g, 15.2 mmol) in ethanol (40 ml) at 0° C. and the reaction mixture was stirred at room temperature overnight. The precipitate was filtered and added to methanol (20 ml). The precipitate was collected by filtration to afford the title compound (4.13 g, 69%) as a white solid.

後処理

  1. filtrationThe precipitate was filtered
  2. additionadded to methanol (20 ml)
  3. filtrationThe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-de7cfd67a4e444bfa6aef484216011e4
出典データセット
uspto-grants-2004_03
特許番号
US06713490B2

反応ノート

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