反応式
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([O:10]C)=O)[CH2:3][CH2:2]1.O.[NH2:13][NH2:14]>C(O)C>[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]([NH:13][NH2:14])=[O:10])[CH2:3][CH2:2]1参加物
4
反応条件
- 温度
- 95 °C
実験手順
In a 25 mL, 3-neck round-bottom flask, methyl 2-morpholinoacetate (0.25 g, 1.0 eq.) was dissolved in ethanol (5 mL) at RT. Hydrazine hydrate (0.087 g, 1.1 eq.) was introduced dropwise at RT and the reaction mixture was refluxed at 95° C. for 20 h. The reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg) to afford the crude 2-morpholinoacetohydrazide (0.23 g) which was used without further purification in the following step.
後処理
- concentrationThe reaction mixture was concentrated under reduced pressure (40° C., 20 mm Hg)
出典と根拠
- ORDレコード
- ord-3b0a93b7c5fc45fb972dc6e5c9848663
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09096543B2
関連ノート
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