Oxalyl chloride → 2-Chloro-6-fluorobenzoyl isocyanate

HRID 508726ノート

反応式

HRID 508726 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:13](Cl)=[O:14]>C(Cl)CCl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([N:6]=[C:13]=[O:14])=[O:5]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 985642-Chloro-6-fluorobenzamide

生成物 1

HCID 130517312-Chloro-6-fluorobenzoyl isocyanate収率 91,106.602%

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

To a solution of 2-chloro-6-fluorobenzamide (2.0 g, 0.011 mmol) in EDC (10 mL) was added oxalyl chloride (2.18 g, 0.017 mmol). The reaction mass was refluxed for 24 h. Excess of solvent was removed under vacuum to afford 2.0 g of desired product.

後処理

  1. temperatureThe reaction mass was refluxed for 24 h
  2. customExcess of solvent was removed under vacuum

出典と根拠

ORDレコード
ord-0820864e80534bdb9430b8e948041a85
出典データセット
uspto-grants-2015_08
特許番号
US09096545B2

反応ノート

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