Hydrochloric Acid → 3-(Difluoromethyl)aniline
反応式
[F:1][CH:2]([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N+:9]([O-])=O)[CH:4]=1.Cl>[Fe].CO>[F:1][CH:2]([F:12])[C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[NH2:9]参加物
5
実験手順
The title compound was prepared according to the procedure described in step-2 of Intermediate-28 by using 1-(difluoromethyl)-3-nitrobenzene (1.0 g, 5.0 mmol), Iron powder (3.0 g, 15.0 mmol), conc. HCl (5 mL) and methanol (20 mL) to afford 0.700 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 5.36 (br s, 2H), 6.62-6.82 (m, 4H), 7.11 (t, J=7.8 Hz, 1H); MS (m/z): 144.05 (M+H)+.
後処理
- customThe title compound was prepared
出典と根拠
- ORDレコード
- ord-67f293c0d71a4e95add993ab22555a82
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09096545B2
反応ノート
読み込み中…