Oxalyl chloride → 5-Cyano-2-(difluoromethyl)nicotinoyl isocyanate

HRID 508908ノート

反応式

HRID 508908 の反応式
[C:1]([C:3]1[CH:4]=[N:5][C:6]([CH:12]([F:14])[F:13])=[C:7]([CH:11]=1)[C:8]([NH2:10])=[O:9])#[N:2].C(Cl)(=O)[C:16](Cl)=[O:17]>C(Cl)Cl>[C:1]([C:3]1[CH:4]=[N:5][C:6]([CH:12]([F:14])[F:13])=[C:7]([CH:11]=1)[C:8]([N:10]=[C:16]=[O:17])=[O:9])#[N:2]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 900193735-Cyano-2-(difluoromethyl)nicotinamide

生成物 1

HCID 900192245-Cyano-2-(difluoromethyl)nicotinoyl isocyanate収率 88.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 5-cyano-2-(difluoromethyl)nicotinamide (1.0 g), oxalyl chloride (3.2 g, 25.3 mmol) and DCM (20 mL) to afford 1.0 g of the desired product.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-160659bb427b4d3d8fd720fb3668c625
出典データセット
uspto-grants-2015_08
特許番号
US09096545B2

反応ノート

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