Ethanol → Ethyl 2-amino-3-(4-bromophenyl)propanoate

HRID 509082ノート

反応式

HRID 509082 の反応式
[NH2:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].O=S(Cl)Cl.[CH3:18][CH2:19]O>>[CH2:18]([O:4][C:3](=[O:5])[CH:2]([NH2:1])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([Br:13])=[CH:11][CH:12]=1)[CH3:19]

参加物

4

反応物 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 856814-Bromophenylalanine

生成物 1

HCID 4016808Ethyl 2-amino-3-(4-bromophenyl)propanoate収率 72%

反応条件

温度
80 °C

実験手順

To a solution of 2-amino-3-(4-bromophenyl)propanoic acid (40 g, 164 mmol) in EtOH (100 mL) was added SOCl2 (30 ml, 422 mmol) dropwise at 80° C. The mixture was stirred at 80° C. for 2 hrs. After the solvent was evaporated, the residue was extracted by EA. The combined organic layers were washed with aqueous NaCl, dried by anhydrous Na2SO4, and concentrated in vacuo to afford ethyl-2-amino-3-(4-bromophenyl)propanoate as a yellow liquid (32 g, yield: 72%).

後処理

  1. customAfter the solvent was evaporated
  2. extractionthe residue was extracted by EA
  3. washThe combined organic layers were washed with aqueous NaCl
  4. dry with materialdried by anhydrous Na2SO4
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-12f89228bd34420f966beb076effc6c4
出典データセット
uspto-grants-2015_08
特許番号
US09096549B2

反応ノート

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