Acetonitrile → (S)-4-(3-methoxybenzyl)-N-(1-(2-cyclopropylthiazol-4-yl)-2-(4-nitrophenyl)ethyl)thiazol-2-amine

HRID 509145

反応式

HRID 509145 の反応式
[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([C@@H:9]([NH:20][C:21]([NH2:23])=[S:22])[CH2:10][C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[N:8]=2)[CH2:3][CH2:2]1.Br[CH2:25][C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([O:34][CH3:35])[CH:29]=1)=O.[CH3:36]C#N>>[CH3:35][O:34][C:30]1[CH:29]=[C:28]([CH:33]=[CH:32][CH:31]=1)[CH2:26][C:25]1[N:23]=[C:21]([NH:20][C@H:9]([C:7]2[N:8]=[C:4]([CH:1]3[CH2:3][CH2:2]3)[S:5][CH:6]=2)[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=2)[S:22][CH:36]=1

参加物

4

反応物 3

HCID 6342AcetonitrileHCID 101294Bromomethyl 3-methoxyphenyl ketoneHCID 59464686(S)-1-(1-(2-Cyclopropylthiazol-4-yl)-2-(4-nitrophenyl)ethyl)-thiourea

生成物 1

HCID 86617185(S)-4-(3-methoxybenzyl)-N-(1-(2-cyclopropylthiazol-4-yl)-2-(4-nitrophenyl)ethyl)thiazol-2-amine

実験手順

(S)-1-(1-(2-Cyclopropylthiazol-4-yl)-2-(4-nitrophenyl)ethyl)-thiourea, 47, (350 mg, 1.00 mmol) and 2-bromo-3′-methoxy-acetophenone (253 mg, 1.10 mmol) are combined in 3 mL CH3CN and heated to reflux for 24 hours. The mixture is concentrated and chromatographed to afford 0.172 g of the product as a yellow solid. LC/MS ESI+ 479 (M+1).

後処理

  1. temperatureheated
  2. temperatureto reflux for 24 hours
  3. concentrationThe mixture is concentrated
  4. customchromatographed

出典と根拠

ORDレコード
ord-ae91a055e3a84b12bb727c278487fa40
出典データセット
uspto-grants-2015_08
特許番号
US09096555B2

関連ノート

読み込み中…