4-(Benzylamino)-1-methylcyclohexanol → Trans-4-amino-1-methyl-cyclohexanol

HRID 509292ノート

反応式

HRID 509292 の反応式
C([NH:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:16])([OH:15])[CH2:11][CH2:10]1)C1C=CC=CC=1>CCO.[Pd]>[NH2:8][CH:9]1[CH2:14][CH2:13][C:12]([CH3:16])([OH:15])[CH2:11][CH2:10]1

参加物

4

反応物 1

HCID 674652054-(Benzylamino)-1-methylcyclohexanol

生成物 1

HCID 18331273Trans-4-amino-1-methyl-cyclohexanol収率 83%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

4-(Benzylamino)-1-methylcyclohexanol (335 mg, 1.53 mmol) was dissolved in EtOH (7.95 ml), followed by addition of Pd (10 wt % on activated carbon, 35 mg), and then the resulting liquid was stirred at room temperature under hydrogen stream for 31 hours. The resulting reaction liquid was filtered, concentrated under reduced pressure, and dried under vacuum, to obtain 164 mg of white solid (83%).

後処理

  1. customThe resulting reaction liquid
  2. filtrationwas filtered
  3. concentrationconcentrated under reduced pressure
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-791d899581944fa1a13752746fd44160
出典データセット
uspto-grants-2015_08
特許番号
US09096571B2

反応ノート

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