Trifluoroacetic acid → (S)-(4-(Trifluoromethyl)phenyl)(3-vinylpyridin-2-yl)methanamine 2,2,2-trifluoroacetate

HRID 509375ノート

反応式

HRID 509375 の反応式
[F:1][C:2]([F:27])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([C@H:9]([NH:18]C(=O)OC(C)(C)C)[C:10]2[C:15]([CH:16]=[CH2:17])=[CH:14][CH:13]=[CH:12][N:11]=2)=[CH:5][CH:4]=1.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[F:31][C:30]([F:33])([F:32])[C:28]([OH:34])=[O:29].[F:27][C:2]([F:1])([F:26])[C:3]1[CH:8]=[CH:7][C:6]([C@@H:9]([C:10]2[C:15]([CH:16]=[CH2:17])=[CH:14][CH:13]=[CH:12][N:11]=2)[NH2:18])=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86687981(S)-tert-butyl ((4-(trifluoromethyl)phenyl)(3-vinylpyridin-2-yl)methyl)carbamate

生成物 1

HCID 86687982(S)-(4-(Trifluoromethyl)phenyl)(3-vinylpyridin-2-yl)methanamine 2,2,2-trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
23 °C

実験手順

To a 50 mL round bottom flask containing (S)-tert-butyl ((4-(trifluoromethyl)phenyl)(3-vinylpyridin-2-yl)methyl)carbamate (97 mg, 0.256 mmol) was added DCM (3 mL). The resulting mixture was then stirred at 23° C. for 2 min. At this time, TFA was added (3 mL) and the reaction was stirred for 3 h. The solvent was removed, and the material was immediately used with no further purification. MS (ESI pos. ion) m/z: 279.1 (M+1).

後処理

  1. stirringthe reaction was stirred for 3 h
  2. customThe solvent was removed
  3. customthe material was immediately used with no further purification

出典と根拠

ORDレコード
ord-8518d249bde84fc290fa8bc562bd8ff0
出典データセット
uspto-grants-2015_08
特許番号
US09096527B2

反応ノート

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