Chlorosuccinimide → 5-Chloro-6-hydroxynicotinic acid
反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[Cl:11]N1C(=O)CCC1=O>CC#N>[Cl:11][C:10]1[C:2](=[O:1])[NH:3][CH:4]=[C:5]([C:6]([OH:8])=[O:7])[CH:9]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution of 6-hydroxy nicotinic acid (0.500 g, 3.59 mmol, TCI) in MeCN (20 mL), was added N-chlorosuccinimide (0.436 mL, 5.39 mmol, Aldrich). The resulting mixture was then heated at 80° C. for 72 h. A white precipitate was present. The mixture was filtered and the white solid was washed with EtOAc (2×1 mL) and dried in vacuo to afford the title compound as a white solid. MS (ESI, positive ion) m/z: 174,176 (M+H).
後処理
- filtrationThe mixture was filtered
- washthe white solid was washed with EtOAc (2×1 mL)
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-ca1438b71a324847a8d9190f6b051e68
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09096527B2
反応ノート
読み込み中…