Acetic Acid → 5-chloro-1H-pyrrolo(2,3-b)pyridine-3-carbaldehyde
反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[CH:10]=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.C1N2CN3CN(C2)CN1C3.[C:21](O)(=[O:23])C>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]([CH:21]=[O:23])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1参加物
5
実験手順
In a round bottom flask, 5-chloro-1H-pyrrolo[2,3-b]pyridine (1, 10.0 g, 65.5 mmol) was combined with hexamethylenetetramine (11.9 g, 85.2 mmol), acetic acid (28.3 mL, 0.498 mol) and 56.7 mL of water. The reaction was heated at reflux overnight, then 200 mL of water was added. After 30 minutes, solid material was collected by filtration and dried to give the desired compound (114, 7.0 g).
後処理
- temperatureThe reaction was heated
- temperatureat reflux overnight
- filtrationsolid material was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-f4d5c70bb0954c4ba840c615a87a0808
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09096593B2
反応ノート
読み込み中…