Thionyl Chloride → 5-Fluoro-2-methoxy-nicotinoyl chloride

HRID 509999ノート

反応式

HRID 509999 の反応式
[F:1][C:2]1[CH:3]=[N:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:15])=O>>[F:1][C:2]1[CH:3]=[N:4][C:5]([O:11][CH3:12])=[C:6]([CH:10]=1)[C:7]([Cl:15])=[O:8]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 404270085-Fluoro-2-methoxynicotinic acid

生成物 1

HCID 582594585-Fluoro-2-methoxy-nicotinoyl chloride

実験手順

In a round bottom flask, 5-fluoro-2-methoxy-nicotinic acid (150, 250 mg, 1.46 mmol) was combined with thionyl chloride (3.00 mL, 41.1 mmol) and the suspension was stirred at room temperature for 3 hours. The reaction was concentrated to dryness under vacuum to provide the desired compound, used in the next step without further purification.

後処理

  1. concentrationThe reaction was concentrated to dryness under vacuum

出典と根拠

ORDレコード
ord-b5896a84eebc46b49bf202c9bb13382c
出典データセット
uspto-grants-2015_08
特許番号
US09096593B2

反応ノート

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